RP-HPLC (STABILITY-INDICATING) BASED ASSAY METHOD FOR THE SIMULTANEOUS ESTIMATION OF DORAVIRINE, TENOFOVIR DISOPROXIL FUMARATE AND LAMIVUDINE

Objective: In this study, a RP-HPLC (stability-indicating) based assay method for the estimation of doravirine (DRV), tenofovir disoproxil fumarate (TFF) and lamivudine (LMV) simultaneously in the tablets was described. Methods: The simultaneous analysis of DRV, TFF and LMV was done with HPLC system (Agilent 1100 series) and Luna Phenomenex C18 (250 mm × 4.6 mm × 5 μ) column with isocratic mobile phase (35% volume ratio of methanol and 65% volume ratio of 20 mmol ammonium formate, pH 5). Validation of assay method was done on sensitivity, linearity, accuracy, selectivity, precision, robustness and specificity. Results: The calibration curves were linear through the range of 25-200 µg/ml for DRV and 75-600 µg/ml for TFF and LMV. The percent relative standard deviation for intraday variation/precision, interday variation/precision, intermediate precision/ruggedness and robustness were lower than 2%. The recovery of LMV (99.09-99.76%), TFF (99.10-99.41%) and DRV (98.65-99.28%) confirmed the good accuracy. The stability of LMV, TFF and DRV in 0.1N NaOH, 3% peroxide, 0.1 N HCl, UV light and dry heat of 60 °C was determined. Conclusion: The results have allowed the method to be implemented in the tablets to quantify DRV, TFF, and LMV

A Proof of Concept for OTFS Resilience in Doubly-Selective Channels by GPU-Enabled Real-Time SDR

Orthogonal time frequency space (OTFS) is a modulation technique which is robust against the disruptive effects of doubly-selective channels. In this paper, we perform an experimental study of OTFS by a real-time software defined radio (SDR) setup. Our SDR consists of a Graphical Processing Unit (GPU) for signal processing programmed using Sionna and TensorFlow, and Universal Software Radio Peripheral (USRP) devices for air interface. We implement a low-latency transceiver structure for OTFS and investigate its performance under various Doppler values. By comparing the performance of OTFS with Orthogonal Frequency Division Multiplexing (OFDM), we demonstrate that OTFS is highly robust against the disruptive effects of doubly-selective channels in a real-time experimental setup.Comment: ACCEPTED for 2023 IEEE Global Communications Conference: Wireless Communication

Me3Al-mediated domino nucleophilic addition/intramolecular cyclisation of 2-(2-oxo-2-phenylethyl)benzonitriles with amines; a convenient approach for the synthesis of substituted 1-aminoisoquinolines

A simple and efficient protocol for the construction of 1-aminoisoquinolines was achieved by treating 2-(2-oxo-2- phenylethyl)benzonitriles with amines in the presence of Me 3 Al. The reaction proceeds via a domino nucleophilic addition with subsequent intramolecular cyclisation. This method provides a wide variety of substituted 1-aminoisoquinolines with good func- tional group tolerance. Furthermore, the synthetic utility of this protocol was demonstrated in the successful synthesis of the anti- tumor agent CWJ-a-5 in gram scale

Phytochemical Analysis Of Avicennia Officinalis Of Krishna Estuary

Phytochemical investigation on the aerial roots of Avicennia officinalis of Krishna estuary, India resulted in the isolation ofthree pentacyclic triterpenoids, betulin aldehyde (1), betulinic acid ( 2) and betulin ( 3). These are characterized byphysical and spectral data. All are known compounds but we are reporting first time from the Krishna estuary species.Compound ( 2) was also possess Cytotoxicity

A catalyst-free, green and efficient protocol for the synthesis of methyleneisoxazole-5(4H)-ones supported by ultrasonic irradiation

A catalyst-free, green and efficient protocol for the one-pot, multi-component, synthesis of Methyleneisoxazole-5(4H)-ones (4a-l) from the reaction of Ethyl acetoacetate, aromatic aldehyde, and hydroxylamine hydrochloride in ethanol as green solvent under ultrasound irradiation at ambient temperature is described. This protocol offers several positive benefits, including simple handling, rapid reaction time period (≤10 mints), easy workup process, waste-free, gentler reaction conditions, ecologically friendly, cleaner reaction, absence of any a laborious purification and excellent yields

An efficient synthesis of 3-fluoro chromones from the tandem cyclization of enaminones by using N-Fluoro benzenesulfonimide

An efficient method of synthesizing the various 3-Fluorochromones from enamino ketones by using N-Fluoro benzenesulfonimide (NFSI) is described. The key step in the synthesis involves tandem cyclization and fluorination to form 3-fluorochromones in good yields. The significant features of this method include simple operational procedures, high purity of the product and cost reducing. This reaction achieved good to excellent yields (51–92%) under ambient conditions with significantly faster rate. The products obtained were confirmed by 1H, 13C NMR and mass spectroscopy techniques.</p